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j WHAT WE KNOW ABOUT <br />l <br />PRENATAL CANNABIS EXPOSURE= <br />41 <br />Cn <br />Cannabinoids 4 lipid soluble, cross the placenta and accumulate in fetal <br />tissues, especially, the brain. <br />Components of the endocannabinoid system are present during embryonic <br />development as early as 16-22 days' gestation in humans. <br />Time of neural plate and neural tube development, the basic scaffold for the forebrain, <br />midbrain, and hindbrain establishment. <br />Several cohort studies have documented modest neurodevelopmental <br />deficits in children, adolescents, and young adults who were prenatally <br />exposed to cannabis (multiple caveats). <br />Recent meta-analysis 4 infants exposed to cannabis in utero have lower <br />birth weight and are more likely to be admitted to the neonatal intensive <br />care unit (NICU) compared to infants without such exposure. <br />Preclinical studies show multiple effects of THC exposure on adult drug <br />seeking behavior, reward and other brain systems, and epigenetic <br />mechanisms. <br />