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AgdaPkt 2017-10-23 Joint SA PFA
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AgdaPkt 2017-10-23 Joint SA PFA
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Last modified
10/24/2017 8:33:20 AM
Creation date
10/19/2017 3:26:13 PM
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Template:
CC Index
CC Index - Document Type
Agenda Packet
Meeting Type
Joint
Agency Type
City Council and Successor Agency and Public Financing Authority
Date
10/23/2017
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Regular Cannabis Use Increases Schizophrenia <br />Cannabis -Associated Psychosis <br />Risk <br />in those with AKT1 rs2494732 genotype <br />Study of Swedish Conscripts (n=45570) <br />30 F <br />L) Never used cannabis <br />■ Used cannabis at week ends or less <br />o <br />5 ■ Used cannabis everyday <br />c <br />20 <br />I= <br />4 <br />-tea <br />3 <br />Q. <br />O <br />H <br />10' <br />0 0 1 2 10 <50 >50 <br />Q <br />AKT1(T/T) AKT(C/T) AKT1(C/C) <br /># of times cannabis used <br />GXE model: p*=0.014 <br />Andreasson et al Lancet, 1987 <br />Di Forti et al., Biological Psychiatry, 2012 <br />..............................................................................:....................................................... <br />Prospective Dunedin study (n=1037) <br />............. <br />Effect of High Potency Cannabis on <br />Risk of Psychosis <br />9 F <br />Risk of schizophrenia -like <br />s� <br />0 7 <br />psychosis at age 26 years <br />Never used cannabis <br />5.4* <br />L 5 <br />4.5 <br />L <br />6 <br />Hash<than weekly <br />Hash at week ends <br />4 <br />1W I <br />Hash daily <br />0 3 <br />1• L <br />v <br />4_ <br />Skunk<than weekly <br />2 <br />Skunk at week ends 2.7* <br />1 <br />.................... ................. ......... <br />■ Skunk daily 1.9) 00 <br />D <br />0 <br />�� <br />2 <br />_ <br />1 0.49 0.62 0.91 <br />Cannabis users Cannabis users <br />Adjusted OR <br />by age 15 years by age 18 years <br />0 <br />- N <br />Arseneault et al BMJ 2002 <br />Di Forti M et al., The Lancet, 2015 <br />
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