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Strength of the Evidence For <br />Marijuana/ c;annaainoia Medical Applications <br />Strongest Evidence Modest Evidence Weakest Evidence <br />Nausea <br />(Cancer chemotherapy) <br />Spasticity and Pain (MS) <br />Appetite Stimulant <br />(AIDS -associated wasting) <br />• Pain esp. neuropathic <br />- Glaucoma <br />(decreases intraocular <br />pressure; no evidence it <br />slows disease progression; <br />and short acting) <br />Anticonvulsant (CBD) <br />Anti-inflammatory (CBD) <br />Antitumor (THC/CBD) <br />(animal models/cell <br />cultures: glioblastoma; <br />breast cancer cells; <br />others (mechanisms: <br />apoptosis; inhibition of <br />tumor angiogenesis) <br />PTSD <br />ADHD <br />Alzheimer's <br />Depression <br />CD <br />CO <br />